Royal College of Surgeons in Ireland, Department of Physiology and Medical Physics, Ireland
Professor Prehn received his PhD in Pharmacology from Philipps-University Marburg, Germany, in 1992. 1993-1994 he was post-doctoral fellow at the Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, USA. 1995-1997 he was employed as a lecturer at the Department of Pharmacology and Toxicology, Philipps-University, Germany. In 1998 he was a recipient of a Junior Research Group award at the Interdisciplinary Center for Clinical Research (IZKF), Westphalian Wilhelms-University Münster, Germany. In 2002 he became a Professor for Experimental Medicine (C3) at the Centre for Neurology and Neurosurgery, Goethe University Clinics, Frankfurt, Germany. Since 2003 he is Professor and a Chairman of the Department of Physiology and Medical Physics, RCSI and since 2006 Director of RCSI Centre for Systems Medicine, RCSI, Ireland.
The main research interests of Professor Prehn is cell death and survival signaling and their relation to cellular and mitochondrial bioenergetics. His group has pioneered the development of systems models of cell death and cell stress signaling, and has translated these approaches into the clinical context of neurodegeneration, cancer and diabetes. Concerning the present neurodegeneration project his main focus is on the mechanisms of excitotoxic and Ca2+-mediated neuronal injury and the evaluation of mitochondrial function and AMPK signaling in neurons, using both quantitative single-cell imaging and computational modelling.